Frequency: Quarterly E- ISSN: 0976-7568 P- ISSN: 2229 -4155 H-Index: 3, RI Factor-2.84, IBI Factor: 3, Global Impact Factor 0.89 Abstracted/ Indexed in: CAS database (a division of the American Chemical Society), Ulrich's International Periodical Directory, Google Scholar, SCIRUS, Genamics Journal Seek, PSOAR, getCITED, JOURNAL directory, InfoBase Index, EBSCO Information Services
Quarterly published in print and online "Inventi Impact: Ethnopharmacology" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under ethnic medicines. It welcomes articles pertaining to empirical knowledge of medicinal substances and their toxic potential as passed-on by oral tradition; scientific study of indigenous medicines; search for pharmacologically unique principles from existing indigenous remedies; formulation, manufacturing and quality control aspects of ethnic medicines.
According to Ayurvedic Systems of Medicine, Abroma augusta Linn. belonging to the family (Malvaceae), was used for treating male sexual dysfunctions, disorders since ancient times. Dependent on Hormonal assay, Body weight, organ weight and histological study of normal male Wister albino rats were investigated and also compared with the test control groups. Animals were divided into one control group (Group I––received saline) and Two experimental groups (Groups II & III). Animals were administered p.o.(per os) with saline or extract once in a day for 14 days. To analyze hormone assay, body weight and sexual organ weights. The extract administered p.o. significantly increased the reproductive behavior of the animals observed. In groups II and III the body weight, testis, seminal vesicle and ventral prostate was significantly increased from that of the controls, after administration of 200 mg or 400 mg doses. Plasma levels of FSH, LH and Testosterone were significantly increased in treatment groups compared to controls (***P<0.001, **P<0.01,) and also Abroma augusta Linn. Treatment showed significantly increased sperm count, sperm motility and spermatogenesis in the treatment group compared with the control group and as per histological data. Therefore, resulting enhanced reproductive functions of the ethanolic extract in male rats....
A traditional belief regarding mode of administration of Asparagus racemosus (AR) says that its Ksheerpaka (milk decoction) is more potent as galactogogue than any other form of dosage. The increase in milk production is theorized to be due to the action of released prolactin. In view of this that milk decoction of AR can stimulate more milk production than aqueous decoction in lactating females because of a capacity to stimulate the prolactin release experiments were performed to compare the effect of aqueous and milk decoction of AR on serum prolactin level in lactating female rats. Females were divided into three experimental groups and treatment was given as follows Group I: Normal control, given with vehicle orally. Group II: Received milk decoction of AR in dose of 200 mg/kg p.o. Group III: Received aqueous decoction AR in dose of 200 mg/kg p.o. All groups had received the decoction for six days starting from day 4 to day 9 of lactation. The animals were then euthanized on day 10 and heart blood samples were analyzed using prolactin kit. The serum prolactin level of the treated milk decoction rats showed significant increase (P<0.05) when compared to control group. This study demonstrates that the milk decoction of AR can stimulate more PRL release than aqueous decoction of AR in the female rat....
Ulcerative colitis is chronically inflammatory bowel disease of unknown origin. This study was undertaken to determine the healing of ulcerative colitis induced by acetic acid due to antioxidant role of kalasakadi kashayam. Kalasakadi kashayam is an ayurvedic proprietary formulation manufactured by Arya Vaidya Sala, kottakkal with proven clinical efficacy. It contains kalasaka (Murraya koenigii Spreng.), Haritaki (Terminalia chebula Retz.) and Sunthi (Zingiber officinale Roxb.). Ulcerative colitis was induced by acetic acid in a dose 2 ml/kg (4% V/V Intrarectal). Ulcerative colitis response was assessed by ulcer index, tissue biochemical parameters, and histopathological examination of colon. The cytoprotective activity of kalasakadi kasayam was assessed at two dose level in comparison to sulfasalazine (360 mg/kg p.o.) as a reference standard drug. Therapeutically Equivalent Dose (TED) of kalasakadi kashayam was 5.4 ml/kg p.o. and double to TED was 10.8 ml/kg p.o. TED and TED × 2 doses restore the decrease level of superoxide dismutase, total glutathione, glutathione peroxidase and increase level of lipid peroxidation, nitric oxide, lactate dehydrogenase, myeloperoxidase activity. In addition kalasakadi kashayam at both dose levels showed significant decrease in ulcer index and histopathological changes of colon. Based on data generated and histopathological profile, it is concluded that kalasakadi kashayam TED level provide more significant protection than kalasakadi kashayam TED × 2 level against acetic acid induced ulcerative colitis....
The present study has examined the antibacterial activity of Euphorbia granulata Forssk aerial parts ethanolic extract using agar disc diffusion method against some Gram-positive and Gram-negative bacteria (Pseudomonas aeruginosa, Listeria monocytogenes, Staphylococcus epidermidis, Staphylococcus aureus, Klebsiella pneumoniae, Salmonella Typhi, Bacillus cereus, Bacillus anthracis, Escherichia coli and Streptococcus pyogenes). This extract had inhibitory effect at different concentrations (0.05, 0.1, 0.2 and 0.4 g ml-1) against above mentioned bacteria. P. aeruginosa and E. coli were the most resistant strains. The highest inhibitory activity of the ethanolic extract (32 mm) was found against S. epidermidis, while the lowest inhibition (7 mm) was demonstrated for B. cereus and L. monocytogenes. The extract exhibited Minimal Inhibitory Concentration (MIC) at 5 mg ml-1 against S. epidermidis and S. aureus, while its Minimal Bactericidal Concentration (MBC) was 5 mg ml-1 and 10 mg ml-1 against S. epidermidis and S. aureus, respectively. Consequently, E. granulata could be as a new source for antibiotic discovery and infection treatment....
The Genus Morinda belongs to family Rubiaceae and about 80 species belongs to this genus. Out of these species 7 species occurs in India. Among the Morinda species Morinda citrifolia is the most noteworthy species which has attained a great prominence in medicinal world in last few years. This species commercially known as noni, is one of the most significant sources of traditional medicines. This small evergreen miracular tree is reported for its extremely wide range of environmental tolerances. It can grow in infertile, acidic, and alkaline soils and grows comfortably in very dry to very wet areas. The fruit is important because of its wide range of therapeutic potentials such as anti-bacterial, anti-viral, anti-tumor, anti-helminthes, analgesic, hypertensive, anti-inflammatory and immune enhancing effects....
The presented review summarizes the information concerning the botany, ethnopharmacology, phytochemistry, biological activity and toxicity of the Brassica nigra plant. This weed has been known to possess analgesic, antibacterial, anti hyperglycaemic, cardiovascular disease, anti cancer activity and anthelmintic activities. A wide range of chemical compounds about 1% sinigrin (allyl¬glucosinolate), a thioglycoside-like compound (a so-calledglucosinolate) of ally isothiocyanate with glucose. By action of the enzyme myrosinase, allyl isothiocyanate, a pungent, lachrymatory and volatile compound, is liberated (0.7% of the dried seed). Besides allyl isothiocyanate, in Romanian Brown Mustard another related compound is found, namely crotonyl isothiocyanate (2-butenylisothiocyanate)....
Herbal drugs have great growth potential in the global market today. The review focus onTurmeric (Curcuma longa L.), a medicinal plant extensively used in traditional medicine as a home remedy for various diseases. Many biological activities of curcumin have come in to light as the research progress. Current research has focused on its antioxidant, hepatoprotective, antiinflammatory, anticarcinogenic, and antimicrobial properties, in addition to its use in cardiovascular disease and gastrointestinal disorders. This review summarizes our current knowledge of pharmacological actions, preclinical and clinical studies, major bioactivities,reported mechanisms of actions, clinical efficacy, safety, possibility of interactions with the conventional drugs, along with research updates on the herb and the avenues for further research. The wide therapeutic potential of the herb justifies further clinical research to evaluate more precisely the favourable effects in order to explore its new areas of therapeutic applications. In addition, checking for its safety and its potential of interactions with various drugs become imperative....
Hyperlipidemia is a disorder of lipid metabolism manifested by elevation of plasma concentrations of the various lipid and lipoprotein fractions, which is the key risk factor for cardiovascular disorders (CVD). Since synthetic drugs have been shown to have side effects, clinical importance of the herbal drugs in treatment of hyperlipidemia has received considerable attention in recent years. Capparis Deciduas F., Ricinus Communis L., and Zizyphus Jujuba L. are traditionally used as antihyperlipidemic drugs as per ayurvedic literature .Hence the present study was undertaken to investigate the antihyperlipidemic effect of a polyherbal formulation, prepared using the above three medicinal plants against Triton WR-1339 and High fat diet induced hyperlipidemia in rats. Hydroalcoholic extract of the polyherbal formulation at 200 and 400 mg/kg dose inhibited the elevation of serum and liver cholesterol and triglyceride levels in hyperlipidemic rats. The extract also significantly decreased 3-hydroxy-3-methylglutaryl- CoA reductase (HMG-CoA reductase) activity. Thus the hydroalcoholic extract of polyherbal formulation at the dose of 200mg/kg and 400mg/kg; p.o. showed good antihyperlipidemic activity in Triton WR-1339 and High cholesterol diet induced hyperlipidemic rats. The probable mechanism of action of the extract may be inhibition of HMG-CoA reductase enzyme pathway....
This paper presents a review of plants identified from various ethnobotanical surveys and folklore medicinal surveys with demonstrated bioactivity in antidiabetic and alpha - glucosidase inhibitory models. This review also identified plant parts with reported activity and where applicable isolated active compounds. This review covers the period 2000 to 2009 and the plants are presented in an alphabetical and tabular form with the family, botanical name, common name, morphological parts or extract used and any isolated active compound. 422 plant species from various families are cited in this review. The plants mostly studied for antidiabetic, hypoglycaemic and alpha-glucosidase inhibitory activities during the study period are Leguminosae (40 spp), Asteraceae/Compositae (37 spp), Euphorbiaceae (16 spp), Rutaceae (11 spp), Cucurbitaceae (12 spp), Rutaceae (11 spp), Lamiaceae (11 spp), Moraceae (11 spp), Ascelpiadaceae (10 spp), Myrtaceae (10 spp), Solanaceae (9 spp). Further more 105 active compounds have been identified as having potential glucose lowering activity. A definitive hypoglycaemic and antidiabetic study of plants from the mostly studied families could lead to novel drugs in the effective management of diabetes mellitus as well as in the management of complications such as cardiovascular diseases and infections associated with Diabetes mellitus....
Limnanthemum indicum (L. indicum.) is being used in the Ayurvedic system of medicine in India for treatment of various diseases. No systematic toxicity study for this plant was described. The present study was undertaken to assess the safety use of this plant in traditional practice. The acute oral toxicity study of aqueous extract of Limnanthemum indicum (AELI) was carried out as per the OECD guidelines 423 in mice and the sub-acute toxicity was carried out at a dose of 200 mg/kg and 400 mg/kg as per OECD 407 guidelines in male and female rats. Mice administered upto 2000 mg/kg as a single dose orally not caused any signs of toxicity or mortality in mice. In sub-acute toxicity study in rats, AELI at two different daily doses of 200 and 400 mg/kg for 28 days exhibited significant variation including the hematological and biochemical parameters. Histopathological examinations showed abnormal architecture suggesting morphological disturbances. Signs of toxicity were observed for mice in acute oral toxicity studies after administration of AELI at a dose of 200 mg/kg. Death/signs of toxicity were observed after oral administration of 400 mg/kg of AELI in sub-acute toxicity study in rats....
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